Compounds and methods for treating tuberculosis infection
US9073941B2 · kind B2 · utility
32Cited by
4References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 28, 2011 |
| Grant date | Jul 7, 2015 |
| Priority date | — |
| Expiry date | Feb 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus, and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.