Inhibitors of atypical protein kinase C and their use in treating hedgehog pathway-dependent cancers
US9073964B2 · kind B2 · utility
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Key dates
| Filing date | Mar 16, 2012 |
| Grant date | Jul 7, 2015 |
| Priority date | — |
| Expiry date | May 25, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.