Patent · US Active

Cyclic peptides, their preparation and their use as inhibitors of the platelet adhesion

US9073975B2 · kind B2 · utility

1Cited by

1References

3Claims

0Family size

Assignee

Sanofi · FR

Inventors

Otmar Klingler · Rodgau, DE
Horst Blum · Frankfurt, DE
Andreas Lindenschmidt · Bad Soden, DE
Hans Matter · Langenselbold, DE

Key dates

Filing date	Jul 27, 2011
Grant date	Jul 7, 2015
Priority date	—
Expiry date	Jul 27, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to compounds of the Formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, X1, X2, X3 and X4 have the meanings indicated in the claims, and which are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb), and are suitable, for example, for the therapy and prophylaxis of athero-thrombotic diseases. The invention furthermore relates to processes for the preparation of compounds of the Formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.