Patent · US Active

Stabilized MAML peptides and uses thereof

US9074009B2 · kind B2 · utility

14Cited by

14References

12Claims

0Family size

Assignees

DANA-FARBER CANCER INSTITUTE, INC. · US
President and Fellows of Harvard College · US

Inventors

James E. Bradner · Weston, US
Raymond E. Moellering · Chicago, US
Gregory L. Verdine · Boston, US

Key dates

Filing date	Jun 4, 2009
Grant date	Jul 7, 2015
Priority date	—
Expiry date	Jun 4, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.