Nanoparticle entrapment of materials

US9074195B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Mark K. Kinnan · Albuquerque, US
• Heidi Gibson · Los Altos Hills, US

Key dates

• Filing date: Mar 10, 2014
• Grant date: Jul 7, 2015
• Expiry date: Mar 10, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5138
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A water-based and surfactant-free microwave synthesis of polymer nanoparticles includes the entrapment of diisopropyl fluorophosphatase (DFPase) within poly(4-vinylpyridine) (PVP) nanoparticles. The resulting nanoparticles are approximately 80-100 nm in diameter and reactive activity of DFPase is maintained after encapsulation.