pH-responsive fluorescent false neurotransmitters and their use

US9075014B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Dalibor Sames · New York, US
• David Sulzer · New York, US
• Minhee Lee · Bellevue, US
• Niko Gubernator · Del Mar, US

Key dates

• Filing date: Jan 28, 2011
• Grant date: Jul 7, 2015
• Expiry date: Jan 28, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/16
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention relates to compounds having the following structure:wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or atom Z is a nitrogen and bonds χ, δ and γ are absent, or atom Z is a nitrogen and bonds χ and δ are present and γ is absent. R1, R2, R3, R4, R5, and R6 are various substituents as described in the specification.