Patent · US Active

Methods for preparation of pharmaceutical intermediates of aliskiren

US9079839B2 · kind B2 · utility

0Cited by

1References

14Claims

0Family size

Inventors

Xuezhi Yin · Changzhou City, CN
Bing Wang · San Jose, US
Ying Ji · 安丰镇, CN
Mingyuan Liu · Changchun, CN

Key dates

Filing date	Jun 16, 2011
Grant date	Jul 14, 2015
Priority date	—
Expiry date	Feb 16, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C41/22
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed are methods for preparation of two pharmaceutical intermediates (I, II) of Aliskiren, said intermediates are obtained by reacting compound of formula I or II and tribromophosphorus oxide. The method replaces the method in the prior art which is using column chromatopraphy to produce the compounds I and II, and overcomes the defect that the method in the prior art hardly carry out in a large-scale industrial production. The product can be purified by recrystallization or vacuum distillation, and the chemical purity of the product is good.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.