Derivatives of APF and methods of use

US9079936B2 · kind B2 · utility

Assignees

• UNIVERSITY OF MARYLAND, BALTIMORE · US
• The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · US
• DEPARTMENT OF VETERANS AFFAIRS · US

Inventors

• Susan K. Keay · Ellicott City, US
• Christopher J. Michejda · North Potomac, US
• Zoltan Szekely · Frederick, US

Key dates

• Filing date: Aug 18, 2009
• Grant date: Jul 14, 2015
• Expiry date: Mar 31, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed. In particular embodiments, the glycopeptide comprises D-proline.