Influenza A virus vaccines and inhibitors

US9079944B2 · kind B2 · utility

Assignees

• The Board of Regents of the University of Texas System · US
• Rutgers, the State University of New Jersey · US

Inventors

• Gaetano T. Montelione · Highland Park, US
• Kalyan Das · Edison, US
• Edward Arnold · Montgomery, US
• Li-Chung Ma · Princeton Junction, US
• Rong Xiao · Princeton, US
• Robert M. Krug · Austin, US
• Karen Y. Twu · San Mateo, US
• Rei-Lin Kuo · Taipei, TW

Key dates

• Filing date: Nov 17, 2014
• Grant date: Jul 14, 2015
• Expiry date: Nov 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16162
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.