Methods for predicting stability and melting temperatures of nucleic acid duplexes
US9081737B2 · kind B2 · utility
1Cited by
6References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 29, 2011 |
| Grant date | Jul 14, 2015 |
| Priority date | — |
| Expiry date | Aug 1, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B25/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention provides methods that more accurately predict melting temperatures for duplex oligomers. The invented methods predict the Tm of chimeric duplexes containing various amounts of locked nucleic acid modifications in oligonucleotide strands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.