Highly permeating terbinafine formulation
US9084754B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2012 |
| Grant date | Jul 21, 2015 |
| Priority date | — |
| Expiry date | Aug 30, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomychosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent; a lower alcohol; and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.