MEK mutations conferring resistance to MEK inhibitors
US9084781B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Dec 10, 2009 |
| Grant date | Jul 21, 2015 |
| Priority date | — |
| Expiry date | May 9, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.