Patent · US Active

Method for preparing acyclovir 2/3 hydrate

US9084792B2 · kind B2 · utility

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8Claims
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Assignee

Inventors

Key dates

Filing dateMar 17, 2010
Grant dateJul 21, 2015
Priority date
Expiry dateJul 2, 2031

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D473/18
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Preparation of acyclovir 2/3 hydrate comprises mixing acyclovir with water at weight ratio of 1:5˜50, dissolving at 50˜100° C., filtering, cooling filtrate at 0˜30° C. to precipitate crystal, collecting the crystal by filtration, and drying the crystal at 0˜150° C. for 0.5˜24 hours to obtain acyclovir 2/3 hydrate. The preparation process is simple and suitable for industrial production. The prepared product has good and stable crystal form.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.