Patent · US Active

Unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and uses thereof

US9085514B2 · kind B2 · utility

5Cited by

0References

29Claims

0Family size

Assignee

EMBL · DE

Inventors

Edward Lemke · Mannheim, DE
Carsten Schultz · Heidelberg, DE
Tilman Plass · Heidelberg, DE
Sigrid Milles · Grenoble, FR
Christine Koehler · Hamm (Sieg), DE

Key dates

Filing date	Feb 3, 2012
Grant date	Jul 21, 2015
Priority date	—
Expiry date	Mar 28, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2602/42
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.