Aconitine compounds, compositions, uses, and preparation thereof

US9085536B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Justin Du Bois · Stanford, US
• Brian M. Andresen · Sharon, US
• Frederic Menard · Menlo Park, US
• Andrew W. Patterson · Somerville, US

Key dates

• Filing date: Mar 15, 2012
• Grant date: Jul 21, 2015
• Expiry date: Feb 24, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compound derivatives of aconitine are provided, in particular derivatives that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier. The subject compounds are useful in treatments, including treatments to modulate neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the aconitine derivatives.