6-alkyl-N-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same

US9085562B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• P. Jeffrey Conn · Brentwood, US
• Craig W. Lindsley · Brentwood, US
• Kyle A. Emmitte · Durham, US
• Alice L. Rodriguez · Nashville, US
• Andrew S. Felts · Brentwood, US
• Carrie K. Jones · Nashville, US
• Brittney S. Bates · Nashville, US
• Brian A. Chauder · Raleigh, US

Key dates

• Filing date: Mar 5, 2012
• Grant date: Jul 21, 2015
• Expiry date: Mar 5, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.