4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases

US9085572B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Ingo Flamme · Bergneustadt, DE
• Jens-Kerim Ergüden · Uerdingen, DE
• Felix Oehme · Wuppertal, DE
• Kai Thede · Leverkusen, DE
• Gunter Karig
• Alexander Kuhl · Hagen, DE
• Hanno Wild · Wuppertal, DE
• Joachim Schuhmacher · Wuppertal, DE
• Peter Kolkhof · Wuppertal, DE
• Lars Bärfacker · Oberhausen, DE
• Joachim Hutter · Leverkusen, DE

Key dates

• Filing date: Aug 24, 2012
• Grant date: Jul 21, 2015
• Expiry date: Feb 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.