Hemoglobin A1c-specific aptamer, hemoglobin-specific aptamer, and applications thereof
US9086406B2 · kind B2 · utility
4Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 25, 2014 |
| Grant date | Jul 21, 2015 |
| Priority date | — |
| Expiry date | Mar 25, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a Hemoglobin A1c-specific aptamer and a Hemoglobin-specific aptamer. The aptamers were selected in vitro using SELEX and a microfluidic chip system. The aptamers established low free energy, thus were more stable than conventional antibodies. The high specificity of the aptamers to Hemoglobin A1c or Hemoglobin allows them to be effectively used in diagnosis of diabetes and/or anemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.