Antibacterial coatings that inhibit biofilm formation on implants
US9089407B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 8, 2012 |
| Grant date | Jul 28, 2015 |
| Priority date | — |
| Expiry date | Oct 8, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/14
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with the surface. As shown in the examples below, clinical observations, digital radiography, and a battery of well-accepted ex vivo analytical methods show that the presence of a hydrophobic polycationic polymer coating, such as N,N-dodecyl,methyl-PEI coating on the surface of a metal implant, was effective in eliminating the clinical signs of infection in vivo in a large animal infection model. Moreover, the coated plates supported bone healing, and in fact decreased healing times, even in the presence of significant bacterial contamination compared to a control.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.