Orally disintegrating tablets and methods of manufacture

US9089490B2 · kind B2 · utility

Assignee

• Aptalis Pharmatech, Inc. · US

Inventors

• Gopi M. Venkatesh · Dayton, US
• Ken Kangyi Qian · Cincinnati, US
• Shyam Vangala · Vandalia, US
• James M. Clevenger · Vandalia, US
• Donald Guenther · Brookville, US

Key dates

• Filing date: Aug 23, 2013
• Grant date: Jul 28, 2015
• Expiry date: Aug 23, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4045
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.