Sericin extracted fabrics

US9089501B2 · kind B2 · utility

Assignee

• Allergan, Inc. · US

Inventors

• Gregory H. Altman · Arlington, US
• Rebecca L. Horan · Arlington, US
• David J. Horan · Westfield, US
• Jingsong Chen · Virginia Beach, US

Key dates

• Filing date: Dec 20, 2013
• Grant date: Jul 28, 2015
• Expiry date: Dec 20, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T442/2566
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.