Patent · US Active

Method of transfection and compositions therefor

US9089508B2 · kind B2 · utility

9Cited by

0References

23Claims

0Family size

Assignee

The University of Melbourne · AU

Inventors

David Charles Jackson · Elmore, AU
Weiguang Zeng · Sydney, AU
Brendon Yew Loong Chua · Melbourne, AU

Key dates

Filing date	Oct 9, 2008
Grant date	Jul 28, 2015
Priority date	—
Expiry date	Jul 31, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2810/855
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group linked to a TLR ligand. These compounds are useful for in vitro and in vivo methods of transfection of TLR-expressing cells. Other aspects of the invention relate to the use of such compounds for repression of gene expression and DNA vaccination approaches.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.