Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
US9090539B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | May 24, 2013 |
| Grant date | Jul 28, 2015 |
| Priority date | — |
| Expiry date | May 24, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/09
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.