Methods for labeling a substrate using a hetero-diels-alder reaction
US9090542B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | May 5, 2011 |
| Grant date | Jul 28, 2015 |
| Priority date | — |
| Expiry date | Apr 2, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for labeling a substrate using a hetero-Diels-Alder reaction are disclosed. The hetero-Diels-Alder reaction includes the reaction of an o-quinone methide (e.g., an o-naphthoquinone methide) with a polarized olefin to form a hetero-Diels-Alder adduct. The o-quinone methide or the polarized olefin can be attached to a surface of a substrate, and the other of the o-quinone methide or the polarized olefin can include a detectable label. The o-quinone methide can conveniently be generated by irradiation of a precursor compound, preferably in an aqueous solution, suspension, or dispersion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.