PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof

US9090594B2 · kind B2 · utility

Assignee

• Jikai Biosciences, Inc. · CN

Inventor

• Yu Ge · Shanghai, CN

Key dates

• Filing date: Feb 10, 2014
• Grant date: Jul 28, 2015
• Expiry date: Feb 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds as represented by Formula I. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection. Also provided are methods for preparing the compounds represented by Formula I.