Preparation of 14-hydroxycodeinone sulfate
US9090620B2 · kind B2 · utility
9Cited by
24References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 21, 2014 |
| Grant date | Jul 28, 2015 |
| Priority date | — |
| Expiry date | Aug 21, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.