Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof

US9090640B2 · kind B2 · utility

Inventors

• Ulrich Bierbach · Saint Paul, US
• Song Ding · Dongguan, CN

Key dates

• Filing date: Aug 30, 2012
• Grant date: Jul 28, 2015
• Expiry date: Aug 30, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D219/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Acridine containing cisplatin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective cisplatin compounds to the nucleus in cancer cells is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C1-6alkylene-phenyl-NH—C(O)—R15, folic acid, αvβ3 integrin RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and/or mixtures thereof; wherein R15 is a peptide.