Base-substituted benzylamine analogs for use as coagulation factor Xa inhibitors, the production and use thereof

US9090658B2 · kind B2 · utility

Assignee

• THE MEDICINES COMPANY (LEIPZIG) GMBH · DE

Inventors

• Jörg Stürzebecher · Erfurt, DE
• Torsten Steinmetzer · Jena, DE
• Andrea Schweinitz · Jena, DE
• Anne Stürzebecher · Weimar, DE
• Daniel Donnecke · Weimar, DE

Key dates

• Filing date: Sep 13, 2004
• Grant date: Jul 28, 2015
• Expiry date: Oct 5, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0821
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to the novel base-substituted benzylamine analogs of general formula (I), wherein A represents P2-P1 with P1═(A) and P2═(B), for use as coagulation factor Xa inhibitors. The invention also relates to the production and use of said analogs in the therapy and prophylaxis of cardiovascular diseases and thromboembolic events.