Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9090688B2 · kind B2 · utility
29Cited by
142References
48Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 22, 2014 |
| Grant date | Jul 28, 2015 |
| Priority date | — |
| Expiry date | Sep 22, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2511/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.