System and method for biphasic transdermal iontophreotic delivery of therapeutic agents

US9095503B2 · kind B2 · utility

Assignee

• InCube Labs, LLC · US

Inventors

• Mir Imran · Los Altos Hills, US
• Mir Hashim · Fremont, US
• Glen W. McLaughlin · Redwood City, US
• Huma Arastu · San Jose, US
• Rekha Vaidyanathan · San Jose, US
• Joel M. Harris · Summit, US
• Radhika Korupolu · Fremont, US
• Andrew Mangogna · San Jose, US
• Chang Jin Ong · Fremont, US
• Sanjay Patel · Palo Alto, US
• Lu Wang · Berkeley, US
• Timothy H. Williams · Palo Alto, US

Key dates

• Filing date: Mar 26, 2012
• Grant date: Aug 4, 2015
• Expiry date: Dec 15, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.