Diagnosis and prognosis of colorectal cancer

US9095549B2 · kind B2 · utility

Assignee

• ELECTROPHORETICS LIMITED · GB

Inventors

• Richard Joubert · Niedernhausen, DE
• Petra Prefot · Wiesbaden, DE
• Gitte Boehm · Frankfurt am Main, DE
• Juergen Arnhold · Rettert, DE
• Claudia Hoehle · Liederbach, DE
• Erhard Neukum · Königstein, DE
• Juergen Schaefer · Lauterbach, DE

Key dates

• Filing date: Dec 15, 2006
• Grant date: Aug 4, 2015
• Expiry date: Jul 5, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/57419
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin C1 protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No. Q9UNM7); aldo-keto reductase family 1 member B10 (SwissProt Acc. No. O60218); fructosamine-3-kinase (SwissProt Acc. No. Q9H479); peripherin (SwissProt Acc. No. P41219); alpha-2-macroglobul…