Bryostatin analogues and methods of making and using thereof

US9096550B2 · kind B2 · utility

Assignee

• University of Utah Research Foundation · US

Inventors

• Gary E. KECK · Salt Lake City, US
• Matthew Kraft · North Palm Beach, US
• Anh Truong · Burlingame, US
• Carina Cristina Sanchez · Somerville, US
• Wei Li · Acton, US
• Jonathan A. Covel · San Diego, US
• Dennie S. Welch · Lake Bluff, US
• Yam B. Poudel · Fremont, US

Key dates

• Filing date: Oct 14, 2010
• Grant date: Aug 4, 2015
• Expiry date: Feb 27, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1892
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.