Arylamino purine derivatives, preparation method and pharmaceutical use thereof

US9096601B2 · kind B2 · utility

Assignees

• CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. · CN
• Sichuan University · CN

Inventors

• Shengyong Yang · Shanghai, CN
• Yuquan Wei · Chengdu, CN

Key dates

• Filing date: Dec 23, 2010
• Grant date: Aug 4, 2015
• Expiry date: Feb 1, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Arylamino purine derivatives represented by formula I and their preparation method are disclosed, wherein each substituent is defined as in the description. The derivatives have an inhibitory effect on non-small cell lung cancer with deletion mutation of exon 19 or L858R point mutation of exon 21 in epidermal growth factor receptor (EGFR).