BCL-2/BCL-XL inhibitors and therapeutic methods using the same

US9096625B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Jianfang Chen · Ann Arbor, US
• Donna McEachern · Ann Arbor, US
• Longchuan Bai · Ann Arbor, US
• Liu Liu · San Diego, US
• Duxin Sun · Ann Arbor, US
• Xiaoqin Li · Ann Arbor, US
• Angelo Aguilar · Ann Arbor, US

Key dates

• Filing date: Jan 15, 2014
• Grant date: Aug 4, 2015
• Expiry date: Jan 15, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.