Patent · US Active

Dipeptide analogs for treating conditions associated with amyloid fibril formation

US9096645B2 · kind B2 · utility

1Cited by

40References

9Claims

0Family size

Assignee

Ramot at Tel-Aviv University Ltd. · IL

Inventors

Ehud Gazit · Ramat HaSharon, IL
Yaniv Amir · Yehud Monosson, IL
Ludmila Buzhansky · Modiin-Maccabim-Reut, IL
Ulrich Abel · Schifferstadt, DE
Anat Frydman-Marom · Nes Ziona, IL

Key dates

Filing date	Nov 15, 2011
Grant date	Aug 4, 2015
Priority date	—
Expiry date	Nov 15, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.