Method for diagnosing a hemoglobin-related disorder

US9097728B2 · kind B2 · utility

Assignees

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• UNIVERSITÉ PARIS-SUD · DE
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR
• Université Paris—Est Créteil Val de Marne · FR

Inventors

• Veronique Baudin-Creuza · Le Kremlin-Bicêtre, FR
• Corinne Vasseur · Le Kremlin-Bicêtre, FR
• Frédéric Galacteros · Créteil, FR

Key dates

• Filing date: Apr 23, 2010
• Grant date: Aug 4, 2015
• Expiry date: Dec 30, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for diagnosing and/or staging a hemoglobin disorder such as β-thalassemia involves contacting a blood sample of a subject with an Alpha-Hemoglobin Stabilizing Protein which may be present on a solid support, and detecting and/or quantifying free α-Hb. Detection or quantification can be achieved by photometry such as HTRF or immunological procedures such as EIA and ELISA. The free α-Hb is compared to a reference value, and can be used to correlate with the diagnosis and/or staging of the hemoglobin disorder for the subject.