Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery

US9101547B2 · kind B2 · utility

Assignee

• Nano and Advanced Materials Institute Limited · CN

Inventors

• Yu Qian · Cambridge, US
• Li ZHANG · Sha Tin, CN
• Zhi Min Wu · Sha Tin, CN
• Li Zhou · Sha Tin, CN
• Wei Jiang · Sunnyvale, US
• Li Ling · Sha Tin, CN
• Qian Luo · Sha Tin, CN
• Xin Guo · Chengdu, CN

Key dates

• Filing date: Jul 30, 2012
• Grant date: Aug 11, 2015
• Expiry date: Oct 30, 2032

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.