Leukemic cell CNS infiltration controlled by notch-induced chemotaxis
US9101559B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | May 10, 2010 |
| Grant date | Aug 11, 2015 |
| Priority date | — |
| Expiry date | Jul 9, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-CCL19 signaling and methods of identifying additional therapeutic agents useful in the methods of the present invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.