Targeting and in vivo imaging of tumor-associated macrophages

US9101674B2 · kind B2 · utility

Assignees

• VIB VZW · BE
• VRIJE UNIVERSITEIT BRUSSEL · BE

Inventors

• Kiavash Movahedi · Frankfurt am Main, DE
• Damya Laoui · Limal, BE
• Steve Schoonooghe · Kessel-Lo, BE
• Geert Raes · Sint-Genesius-Rode, BE
• Patrick De Baetselier · Berchem, BE
• Jo Van Ginderachter · Ninove, BE
• Nick Devoogdt · Zemst, BE
• Tony Lahoutte · Ganshoren, BE

Key dates

• Filing date: May 24, 2012
• Grant date: Aug 11, 2015
• Expiry date: May 24, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/35
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.