Cell-independent fabrication of tissue equivalents

US9101693B2 · kind B2 · utility

Assignee

• UCL BUSINESS PLC · GB

Inventors

• Robert Brown · Lake Hiawatha, US
• Showan Nazhat · Montréal, CA
• Vivek Mudera · London, GB
• Mike Wiseman · London, GB

Key dates

• Filing date: Jul 5, 2005
• Grant date: Aug 11, 2015
• Expiry date: May 14, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P41/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organized biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibers of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.