Multifunctional radical quenchers for the treatment of mitochondrial dysfunction
US9102626B2 · kind B2 · utility
9Cited by
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19Claims
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Key dates
| Filing date | Apr 4, 2012 |
| Grant date | Aug 11, 2015 |
| Priority date | — |
| Expiry date | Apr 4, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5079
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A):and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.