Patent · US Active

1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof

US9102631B2 · kind B2 · utility

3Cited by

0References

3Claims

0Family size

Assignee

IMPACT THERAPEUTICS, INC. · CN

Inventors

Suixiong Cai · 安丰镇, CN
Ye Tian · Bloomington, US
Lizhen Wu · 安丰镇, CN
Lijun Liu · 安丰镇, CN
Xiaozhu WANG · 安丰镇, CN
Yangzhen Jiang · 安丰镇, CN
Guoxiang Wang · 安丰镇, CN
Xiuyan Zhang · 安丰镇, CN
Qingbing Xu · 安丰镇, CN
Zheng Meng · 安丰镇, CN

Key dates

Filing date	Nov 1, 2012
Grant date	Aug 11, 2015
Priority date	—
Expiry date	Nov 1, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D495/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are novel 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs thereof, represented by the Formula 1:wherein Ar, A, R1, R3-R6 are defined herein. Compounds having Formula I are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity, such as cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.