N-arylaminomethylene benzothiophenones for treatment of cardiovascular disease

US9102667B2 · kind B2 · utility

Assignee

• Forschungsverbund Berlin e.V. · DE

Inventors

• Enno Klussmann · Berlin, DE
• Walter Rosenthal · Kleinmachnow, DE
• Jelena Milic · Berlin, DE
• Martin Bergmann · Linz, AT

Key dates

• Filing date: Jan 18, 2012
• Grant date: Aug 11, 2015
• Expiry date: Jan 18, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases:wherein E is S, O, or CH2, D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.