Sulfonaminoquinoline hepcidin antagonists

US9102688B2 · kind B2 · utility

Assignee

• Vifor (International) AG · CH

Inventors

• Wilm Buhr · Konstanz, DE
• Susanna Burckhardt · Zürich, CH
• Franz Dürrenberger · Dornach, CH
• Felix Funk · Winterthur, CH
• Peter Geisser · Sankt Gallen, CH
• Vincent A. Corden · Stanford in the Vale, GB
• Stephen Martin Courtney · Woodstock, GB
• Graham Dawson · Woodstock, GB
• Tara Davenport · Abingdon, GB
• Mark Slack · Hamburg, DE
• Mark Peter Ridgill · Watton-at-Stone, GB
• Christopher John Yarnold · Shrewsbury, GB
• Susan Boyce · Quickborn, DE
• Albertus A. Ellenbroek · Wellington, NZ

Key dates

• Filing date: Jun 20, 2014
• Grant date: Aug 11, 2015
• Expiry date: Jun 20, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.