Synthesis of sialooligosaccharide derivatives

US9102966B2 · kind B2 · utility

Assignee

• GLYCOM A/S · DK

Inventors

• Andreas Schroven · Templin, DE
• Elise Champion · Paris, FR
• Gyula Dekany · Budapest, HU
• Christoph Röhrig · Clingen, DE
• Ioannis Vrasidas · Thessaloniki, GR
• Ignacio Figueroa Pérez · Miami, US
• Markus Hederos · Svedala, SE
• Julien Boutet · Saint-Nazaire, FR
• Ágnes Ágoston · Zsámbék, HU
• Piroska Kovács-Pénzes · West Babylon, US
• Ferenc Horváth · Pilisszentkereszt, HU
• Christian Risinger · Rottweil, DE
• Gergely Pipa · Budapest, HU
• Sándor Demkó · Debrecen, HU
• Lars Kröger · Hamburg, DE

Key dates

• Filing date: Jul 15, 2011
• Grant date: Aug 11, 2015
• Expiry date: Dec 27, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.