Small diameter vascular graft produced by a hybrid method

US9107739B2 · kind B2 · utility

Assignees

• DREXEL UNIVERSITY · US
• THE CHILDREN'S HOSPITAL OF PHILADELPHIA · US
• The Trustees of the University of Pennsylvania · US

Inventors

• Peter I. Lelkes · Cherry Hill, US
• Mengyan Li · Tampa, US
• Anat Perets · Narberth, US
• Pimporn Uttayarat · Philadelphia, US
• Robert J. Levy · Yeadon, US
• Russell Composto · Philadelphia, US

Key dates

• Filing date: Nov 24, 2010
• Grant date: Aug 18, 2015
• Expiry date: Jun 7, 2031

Classification

• Technology area (CPC D): Textiles; Paper
• CPC primary: D10B2509/06
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.