Patent · US Active

Immunostimulatory compositions and methods of use thereof

US9107904B2 · kind B2 · utility

7Cited by
2References
26Claims
0Family size

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Inventors

Key dates

Filing dateMar 15, 2013
Grant dateAug 18, 2015
Priority date—
Expiry dateMar 15, 2033

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02A50/30
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.