Methods of selecting and using therapeutic and prophylactic probiotic cultures to reduce bacterial pathogen loads

US9107938B2 · kind B2 · utility

Assignees

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US
• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• Daniel Donoghue · Oregon, US
• Ann M. Donoghue · Springdale, US

Key dates

• Filing date: Sep 30, 2011
• Grant date: Aug 18, 2015
• Expiry date: Sep 30, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2035/11
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods are provided for selecting a bacterium capable of reducing pathogenic bacterial colonization of the intestinal tract in a subject comprising selecting the bacterium capable of migrating at least 0.75 cm from the point of inoculation on motility agar after incubation for 24 hours at 37° C. or capable of migrating from the point of inoculation to a diameter of at least 1.5 cm based on the farthest colonies from the point of inoculation on motility agar after incubation for 24 hours at 37° C. Bacteria selected using the method and compositions comprising these bacteria are also provided.