Serinol production in glycerol catabolism deficient Escherichia coli strains

US9109240B2 · kind B2 · utility

Assignees

• BASF SE
• WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER · DE

Inventors

• Lukas Maksym · Cologne, DE
• Alexander Steinbuechel · Havixbeck, DE
• Bjoern Andreessen · Munster, DE

Key dates

• Filing date: Sep 5, 2013
• Grant date: Aug 18, 2015
• Expiry date: Sep 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/90
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention is about E. coli host cells which are capable to convert glycerol to serinol. Furthermore, a process for producing serinol is disclosed, which comprises culturing E. coli host cells inactive for triosephosphate isomerase and active for dihydroxyacetone phosphate aminotransferase to convert glycerol to serinol, induction of conversion from glycerol to serinol by adding at least glycerol to the cell culture, and isolating serinol from the cell culture.