Nanotopography-mediated reverse uptake platform for nucleic acid delivery and applications thereof
US9114092B2 · kind B2 · utility
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Key dates
| Filing date | Jan 28, 2013 |
| Grant date | Aug 25, 2015 |
| Priority date | — |
| Expiry date | Jan 28, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application discloses a nanotopography-mediated reverse uptake (NanoRU) platform useful for intracellular delivery of nucleic acids into mammalian cells, in particular stem cells, as well as methods of preparation and applications thereof. In particular, this system can be used to deliver small interfering ribonucleic acids (siRNAs) into neural stem cells and enhance neuronal differentiation of the stem cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.